Besides, unruptured epidermal cysts reveal branching telangiectasia, but ruptured epidermal cysts display peripheral, linear, branched vessels (45). Reference (5) describes the dermoscopic appearance of steatocystoma multiplex and milia as presenting with a peripheral brown ring, linear vessels within the lesion, and a uniform yellow backdrop covering the entire affected area. Another crucial observation is that while other previously mentioned cystic lesions are marked by linear vessels, pilonidal cysts are marked by a unique pattern of dotted, glomerular, and hairpin-shaped vessels. Among the differential diagnoses for pink nodular lesions are pilonidal cyst disease, amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma (3). In our cases and two existing case reports, common dermoscopic signs of pilonidal cyst disease appear to include a pink background, central ulceration, a peripheral distribution of dotted vessels, and the presence of white lines. Pilonidal cyst disease is characterized, as demonstrated by our observations, by the presence of central yellowish, structureless regions, as well as peripheral hairpin and glomerular vessels within its dermoscopic presentation. Ultimately, the previously mentioned dermoscopic signs allow for a clear differentiation of pilonidal cysts from other skin tumors, and dermoscopy supports a clinical diagnosis of pilonidal cyst in appropriate cases. Subsequent studies are essential for a more precise depiction of the common dermoscopic features and their prevalence in this condition.

To the esteemed Editor, segmental Darier disease (DD) presents as a rare condition, with approximately 40 documented instances in the English medical literature. A hypothesis posits a post-zygotic somatic mutation within the calcium ATPase pump, limited to lesional skin, as a potential driver of the disease. Unilaterally, along Blaschko's lines, segmental DD type 1 presents lesions; in contrast, segmental DD type 2, in patients with generalized DD, displays focused zones of heightened severity (1). A positive family history is often absent, and the late onset of type 1 segmental DD, typically in the third or fourth decade, along with the lack of associated features, all conspire to make diagnosis difficult. Linear or zosteriform distributions of acquired papular dermatoses, including lichen planus, psoriasis, lichen striatus, and linear porokeratosis, constitute elements within the differential diagnosis of type 1 segmental DD (2). We report two instances of segmental DD, with the first case being a 43-year-old female who experienced pruritic skin manifestations lasting five years, accompanied by seasonal exacerbations. Upon examination, a swirling arrangement of small, keratotic papules, ranging in color from light brownish to reddish, was noted on the left abdominal and inframammary regions (Figure 1a). Figure 1, subfigure b, showed dermoscopic patterns of polygonal or roundish, yellowish-brown regions, bordered by an expanse of whitish, structureless tissue. flow-mediated dilation The histopathological correlation between dermoscopic brownish polygonal or round areas and the presence of hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes in the biopsy specimen (Figure 1, c) is noteworthy. The patient experienced notable improvement, documented in Figure 1, part d, after being prescribed 0.1% tretinoin gel. In the second case, a 62-year-old female presented with a zosteriform rash on her right upper abdomen, consisting of small red-brown papules, eroded papules, and yellowish crusts (Figure 2a). A dermoscopic examination revealed polygonal, roundish, yellowish areas encircled by a structureless halo of whitish and reddish pigmentation (Figure 2b). The histopathological analysis indicated prominent compact orthokeratosis interspersed with small parakeratosis foci, a granular layer containing dyskeratotic keratinocytes, and the presence of suprabasal acantholytic areas, strongly suggesting the diagnosis of DD (Figure 2, d, d). The patient's condition manifested improvement subsequent to being prescribed topical steroid cream and 0.1% adapalene cream. A diagnosis of type 1 segmental DD was established in both cases through the combination of clinical and histopathological information; the histopathology report could not definitively exclude acantholytic dyskeratotic epidermal nevus, which presents identically to segmental DD both clinically and microscopically. The diagnosis of segmental DD was substantiated by the late age of symptom onset and the subsequent worsening prompted by external factors like heat, sunlight, and perspiration. Clinico-histopathological assessment typically forms the basis for a conclusive type 1 segmental DD diagnosis; however, dermoscopy is instrumental in the diagnostic process by narrowing down the differential possibilities, recognizing their distinctive dermoscopic hallmarks.

Condyloma acuminatum, while not commonly found in the urethra, typically manifests in the distal part when it does affect the urethra. Several methods for treating urethral condylomas have been outlined. Laser treatment, electrosurgery, cryotherapy, and topical applications of cytotoxic agents, including 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod, constitute these extensive and diverse treatments. Laser therapy remains the preferred method for treating intraurethral condylomata. A case of meatal intraurethral warts in a 25-year-old male patient is presented, where 5-FU proved successful after numerous failed treatments, including laser treatment, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid.

Erythroderma and generalized scaling serve as hallmarks of a heterogeneous group of skin disorders, ichthyoses. The nature of the connection between ichthyosis and melanoma remains poorly understood. An elderly patient with congenital ichthyosis vulgaris presents here with an unusual case of palm acral melanoma. Through the process of biopsy, a melanoma with ulceration and a superficial spreading pattern was diagnosed. Our current data reveals no instances of acral melanoma in patients who have congenital ichthyosis. In spite of this, the risk of invasion and metastasis necessitates regular clinical and dermatoscopic screenings for melanoma in patients with ichthyosis vulgaris.

A 55-year-old male, the subject of this report, was found to have penile squamous cell carcinoma (SCC). Avasimibe A mass, increasing in size over time, was observed within the patient's penis. The surgical procedure involved a partial penectomy for mass removal. Upon microscopic examination, a well-differentiated squamous cell carcinoma was identified. A polymerase chain reaction test detected the genetic material of human papillomavirus (HPV). Squamous cell carcinoma was identified as harboring HPV, specifically type 58, according to sequencing.

Diverse genetic syndromes frequently display a concurrence of cutaneous and extracutaneous abnormalities, a phenomenon extensively characterized by medical professionals. Although much is known, further syndromic patterns, as of yet unrecorded, could potentially exist. renal biomarkers This report describes the case of a patient admitted to the Dermatology Department due to multiple basal cell carcinomas that arose from a pre-existing nevus sebaceous. In conjunction with the cutaneous malignancies, the patient presented with palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine fibroid, an ovarian cyst, and a highly dysplastic colon adenoma. Simultaneous presentation of multiple disorders could imply a hereditary origin for these illnesses.

Inflammation of small blood vessels, following drug exposure, leads to the development of drug-induced vasculitis and potential tissue damage. Reports in the medical literature have documented rare cases of drug-induced vasculitis stemming from the use of chemotherapy or concurrent chemoradiotherapy. A medical diagnosis of small cell lung cancer (SCLC), stage IIIA (cT4N1M0), was confirmed in our patient's case. Subsequent to the second cycle of carboplatin and etoposide (CE) chemotherapy, four weeks later, the patient exhibited cutaneous vasculitis and a rash confined to the lower extremities. The discontinuation of CE chemotherapy was followed by the administration of methylprednisolone for symptomatic management. The prescribed corticosteroid medication proved effective in improving the local situation. After chemo-radiotherapy was completed, the patient's treatment continued with four cycles of consolidation chemotherapy which included cisplatin, for a total of six chemotherapy cycles. The clinical assessment indicated a more pronounced decrease in the cutaneous vasculitis. Upon completion of the consolidation chemotherapy, elective radiotherapy for the brain was given. Clinical monitoring of the patient was maintained until the disease's recurrence. Chemotherapy treatments for the platinum-resistant disease continued with subsequent lines. Subsequent to the SCLC diagnosis by seventeen months, the patient expired. In our review of existing literature, we have identified this as the first described occurrence of lower limb vasculitis in a patient receiving both radiotherapy and CE chemotherapy concurrently, as part of the primary therapeutic strategy for SCLC.

The occupational hazard of allergic contact dermatitis (ACD), specifically that caused by (meth)acrylates, often affects dentists, printers, and fiberglass workers. The deployment of artificial nails has been associated with documented instances of problems affecting both nail technicians and clients who utilize them. The use of (meth)acrylates in artificial nails, leading to ACD, presents a significant concern for both nail technicians and customers. A 34-year-old woman, after working for two years in a nail art salon, encountered severe hand dermatitis, particularly on her fingertips, combined with recurrent facial dermatitis. The patient's nails, prone to splitting, necessitated the use of artificial nails for the past four months, complemented by regular gel applications for reinforcement. She reported multiple incidents of asthma during her time at the office. The baseline series, acrylate series, and the patient's own material were subjected to patch testing.